MF498|EP4 inhibitor|DC Chemicals

MF498|EP4 inhibitor|DC Chemicals

MF498 is a novel and selective E prostanoid receptor 4 (EP4) inhibitor, relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis.

Product name: MF498 |Cat No. DC8249|Other names: MF498,MF-498,MF 498|Cas: 915191-42-3|Molecule Weight: 603.7|Molecule Formular: C32H33N3O7S| Purity: >98%

MF498 is a selective EP4 receptor antagonist (Ki = 0.7 nM versus a Ki > 1 µM for other EP receptors).In HEK293 cells expressing the human EP4 receptor, MF498 inhibits EP ligand induced activity with an IC50 value of 1.7 nM.In various animal models for arthritis, MF498 has been shown to inhibit inflammation without gastrointestinal toxicity (ED50 values as low as 0.02 mg/kg/day).

For research and scientific purpose only, not for human use.