AZD-8186|AZD8186|PI3K/δ inhibitor|DC Chemicals

AZD-8186|AZD8186|PI3K/δ inhibitor|DC Chemicals

AZD8186 is an inhibitor of PI3Kβ and PI3Kδ.

Product name: AZD8186 |Cat No. DC8228|Other names: AZD-8186，AZD 8186|Cas: 1296270-45-5|Molecule Weight: 457.47
|Molecule Formular: C24H25F2N3O4| Purity: >98%

In vitro, AZD8186 inhibited growth of a range of cell lines. Sensitivity was associated with inhibition of the AKT pathway. Cells sensitive to AZD8186 (GI50 < 1 μmol/L) are enriched for, but not exclusively associated with, PTEN deficiency. In vivo, AZD8186 inhibits PI3K pathway biomarkers in prostate and TNBC tumors. Scheduling treatment with AZD8186 shows antitumor activity required only intermittent exposure, and that increased tumor control is achieved when AZD8186 is used in combination with docetaxel. AZD8186 is a potent inhibitor of PI3Kβ with activity against PI3Kδ signaling, and has potential to reduce growth of tumors dependent on dysregulated PTEN for growth. Moreover, AZD8186 can be combined with docetaxel, a chemotherapy commonly used to treat advanced TBNC and prostate tumors. The ability to schedule AZD8186 and maintain efficacy offers opportunity to combine AZD8186 more effectively with other drugs.

For research and scientific purpose only, not for human use.