MI-3 (ML3,Menin-MLL Inhibitor)|DC Chemicals

MI-3 (ML3,Menin-MLL Inhibitor)|DC Chemicals

MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM.

Product name: MI-3 (Menin-MLL Inhibitor) |Cat No. DC8246|Other names: MI-3，MI3|Cas: 1271738-59-0|Molecule Weight: 375.55|Molecule Formular: C18H25N5S2| Purity: >98%

In HEK293 cells, MI-3 accesses the protein target and effectively inhibits the menin-MLL-AF9 interaction. MI-3 effectively blocks MLL fusion protein-mediated leukemic transformation by downregulating the expression of target genes required for MLL fusion protein oncogenic activity. In human MLL leukemia cell lines harboring different MLL translocations, MI-3 effectively blocks cell proliferation, and induces apoptosis.

For research and scientific purpose only, not for human use.