SAG|Smoothened (Smo) receptor agonist|DC Chemicasl

SAG|Smoothened (Smo) receptor agonist|DC Chemicasl

SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM).

Product name: SAG |Cat No. DC8225|Other names: SAG,912545-86-9|Cas: 912545-86-9|Molecule Weight: 490.06|Molecule Formular: C28H28ClN3OS| Purity: >98%

The binding of BODIPY-cyclopamine to the Smo-deletion mutants was inhibited by 150 nM SAG to an extent similar to that observed with cells expressing WT Smo. SAG may interact not only with Smo, but also with a cellular effector of Smo activation, thereby inducing Hh pathway activation by facilitating the association of these two proteins at optimal SAG concentrations.

For research and scientific purpose only, not for human use.