PNRI-299(PNRI299)|AP-1 inhibitor|DC Chemicals

PNRI-299(PNRI299)|AP-1 inhibitor|DC Chemicals

PNRI-299 is an inhibitor of activator protein-1 (AP-1) transcription (IC(50) of 20 microM) without affecting NF-kappaB transcription (up to 200 microM) or thioredoxin (up to 200 microM).

Product name: PNRI-299 |Cat No. DC8234|Other names: PNRI299,PNRI-299,PNRI 299|Cas: 550368-41-7|Molecule Weight: 401.37|Molecule Formular: C21H15N5O4| Purity: >98%

PNRI-299, was identified that selectively inhibited AP-1 transcription (IC(50) of 20 microM) without affecting NF-kappaB transcription (up to 200 microM) or thioredoxin (up to 200 microM). The molecular target of PNRI-299 was determined to be the oxidoreductase, redox effector factor-1 by an affinity chromatography approach. The selective redox effector factor-1 inhibitor, PNRI-299, significantly reduced airway eosinophil infiltration, mucus hypersecretion, edema, and IL-4 levels in a mouse asthma model. These data validate AP-1 as an important therapeutic target in allergic airway inflammation.

For research and scientific purpose only, not for human use.