FG2216|HIF-prolyl hydroxylase inhibitor|DC Chemicals

FG2216|HIF-prolyl hydroxylase inhibitor|DC Chemicals

FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme; orally bioavailable and induced significant and reversible Epo induction in vivo.

Product name: FG2216 |Cat No. DC8195|Other names: FG2216|Cas: 223387-75-5|Molecule Weight: 280.66|Molecule Formular: C12H9ClN2O4| Purity: >98%

FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme; orally bioavailable and induced significant and reversible Epo induction in vivo.
FG-2216 was orally bioavailable and induced significant and reversible Epo induction in vivo (82- to 309-fold at 60 mg/kg). Chronic oral dosing in male rhesus macaques was well tolerated, significantly increased erythropoiesis, and prevented anemia induced by weekly phlebotomy. Furthermore, modest increases in HbF-containing red cells and reticulocytes were demonstrated by flow cytometry, though significant increases in HbF were not demonstrated by high-pressure liquid chromatography (HPLC).

For research and scientific purpose only, not for human use.