AS 602801(Bentamapimod)|JNK Inhibitor|DC Chemicals

AS 602801(Bentamapimod)|JNK Inhibitor|DC Chemicals

AS 602801(Bentamapimod) is a novel, orally active inhibitor of JNK.

Product name: AS 602801(Bentamapimod) |Cat No. DC8256|Other names: AS-602801 ,Bentamapimod  ,AS602801|Cas: 848344-36-5|Molecule Weight: 457.55|Molecule Formular: C25H23N5O2S| Purity: >98%

AS 602801(Bentamapimod) is a novel, orally active inhibitor of JNK.In activated PBMCs from HVs, we showed that AS602801 blocked T-lymphocyte proliferation and induced apoptosis. In RRMS CD4+ and CD8+ cells, AS602801 induced apoptosis genes and expression of surface markers, while in RRMS CD11b+ cells it induced expression of innate immunity receptors and co-stimulatory molecules. Untreated cells from RRMS active-phase patients significantly released interleukin-23 (IL-23) and interferon-gamma (IFN-γ) and expressed less apoptosis markers compared to the cells of HVs.

For research and scientific purpose only, not for human use.