Pyridoclax(MR29072)|MR-29072,MR 29072|DC Chemicals

Pyridoclax(MR29072)|MR-29072,MR 29072|DC Chemicals
Pyridoclax(MR-29072) is a potent Mcl-1 inhibitor with Kd value of 25 nM.

Product name: Pyridoclax(MR29072) |Cat No. DC8128|Other names: Pyridoclax(MR29072),MR-29072,MR 29072|Cas: 1651890-44-6|Molecule Weight: 426.51|Molecule Formular: C29H22N4| Purity: >98%

Pyridoclax is able to disrupt BimL/Mcl-1 interaction in whole living cells. Pyridoclax strongly sensitizes ovarian cancer chemoresistant IGROV1-R10 cells to Bcl-xL targeting siRNA, their combination leading to massive apoptosis. Neither ABT-737 nor Pyridoclax induced cell death as single agents, whereas their combination led to massive apoptotic cell death in both IGROV1-R10 and SKOV3 chemoresistant ovarian cancer cell lines.

For research and scientific purpose only, not for human use.