L-189|NHEJ inhibitor|CRISPR Editing|DC Chemicals

L-189|NHEJ inhibitor|CRISPR Editing|DC Chemicals
L-189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki = 5 μM for DNA ligase I).

Product name: L-189 |Cat No. DC8136|Other names: L-189,L 189,L189|Cas: 64232-83-3|Molecule Weight: 246.293|Molecule Formular: C11H10N4OS| Purity: >98%

DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki = 5 μM for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.

For research and scientific purpose only, not for human use.