MK-8776 (SCH 900776) supplier|cas 891494-63-6 |DC Chemicals|Supplier|Price|Buy 

MK-8776 (SCH 900776) supplier|cas 891494-63-6 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: MK-8776 (SCH 900776) supplier,cas 891494-63-6, Cat No. DC5024, In stock

Contact: website: www.dcchemicals.com,

sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,

Tel: +86-21-61454686;Fax:+86-21-61642797；

Product name: MK-8776 (SCH 900776), Synonym:　SCH-900776; SCH 900776,  MK-8776., Cat No. DC5024, Cas: 891494-63-6, Chemical Name:N/A, Molecular Formula: C15H18BrN7, MW: 376.25

MK-8776 (SCH 900776),cas 891494-63-6, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. SCH 900776 is a selective Chk1 inhibitor with IC50 of 3 nM. It shows 50-fold selectivity against Chk2. Phase 2.

SCH900776, also known as  MK-8776.  is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. Chk1 inhibitor SCH 900776 specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents. Chk1 is an ATP-dependent serine-threonine kinase that in response to DNA damage phosphorylates cdc25 phosphatases, resulting in inhibitory tyrosine phosphorylation of CDK-cyclin complexes and cell cycle arrest.