PFI-1 (PF-6405761) supplier|cas 1403764-72-6 |DC Chemicals|Supplier|Price|Buy  

PFI-1 (PF-6405761) supplier|cas 1403764-72-6 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: PFI-1 (PF-6405761) supplier,cas 1403764-72-6, Cat No. DC5025, In stock

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Product name: PFI-1 (PF-6405761), Synonym:　N/A, Cat No. DC5025, Cas: 1403764-72-6, Chemical Name:2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide, Molecular Formula: C16H17N3O4S, MW: 347.39

PFI-1 (PF-6405761),cas 1403764-72-6, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. PFI-1 is a selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM.

PFI-1 is a potent and  highly selective protein interaction Inhibitor, which targets BET bromodomain.  PFI-1 that efficiently blocks the interaction of BET BRDs with acetylated histone tails. Co-crystal structures showed that PFI-1 acts as an acetyl-lysine (Kac) mimetic inhibitor efficiently occupying the Kac binding site in BRD4 and BRD2. PFI-1 has antiproliferative effects on leukaemic cell lines and efficiently abrogates their clonogenic growth. Exposure of sensitive cell lines with PFI-1 results in G1 cell cycle arrest, down-regulation of MYC expression as well as induction of apoptosis and induces differentiation of primary leukaemic blasts. Intriguingly, cells exposed to PFI-1 showed significant down-regulation of Aurora B kinase, thus attenuating phosphorylation of the Aurora substrate H3S10 providing an alternative strategy for the specific inhibition of this well established oncology target.