Monomethyl auristatin E (MMAE, vedotin) Supplier
DC Chemicals provide Monomethyl auristatin E (MMAE, vedotin).
CAS#:474645-27-7
Purity of current batch: 98.98%
Molecular Weight:717.98
Formula:C39H67N5O7
Purity of current batch: 98.98%
Molecular Weight:717.98
Formula:C39H67N5O7
In stock
Biological Activity:
Monomethyl auristatin E (MMAE, vedotin) is a very potent anti-mitotic agent that inhibits cell division by
blocking the polymerisation of tubulin. Because of its super toxicity, it cannot be used as a drug itself. In recent cancer therapy developments, it is linked to a monoclonal antibody (mAb) that recognizes a
specific marker expression in cancer cells and directs MMAE to the cancer cells. The linker linking MMAE to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the
antibody-drug-conjugate/ADC has bound to the specific cancer cell antigen and entered the cancer cell,thus releasing the toxic MMAE and activating the potent anti-mitotic mechanism.
Monomethyl auristatin E (MMAE, vedotin) is a very potent anti-mitotic agent that inhibits cell division by
blocking the polymerisation of tubulin. Because of its super toxicity, it cannot be used as a drug itself. In recent cancer therapy developments, it is linked to a monoclonal antibody (mAb) that recognizes a
specific marker expression in cancer cells and directs MMAE to the cancer cells. The linker linking MMAE to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the
antibody-drug-conjugate/ADC has bound to the specific cancer cell antigen and entered the cancer cell,thus releasing the toxic MMAE and activating the potent anti-mitotic mechanism.
Contact:
EMAIL:sales@dcchemicals.com
Phone:+86-21-61454686,Fax:+86-21-61642470
EMAIL:sales@dcchemicals.com
Phone:+86-21-61454686,Fax:+86-21-61642470
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