Tivozanib(AV-951) supplier|cas 475108-18-0 |DC Chemicals|Supplier|Price|Buy  

Tivozanib(AV-951) supplier|cas 475108-18-0 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Tivozanib(AV-951) supplier,cas 475108-18-0, Cat No. DC5078, In stock

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Product name: Tivozanib(AV-951), Synonym:　AV-951; KRN951., Cat No. DC5078, Cas: 475108-18-0, Chemical Name:N/A, Molecular Formula: C22H19ClN4O5, MW: 454.86306

Tivozanib(AV-951),cas 475108-18-0, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. Tivozanib (AV-951, KRN-951) is a potent and selective VEGFR inhibitor for VEGFR1/2/3 with IC50 of 0.21 nM/0.16 nM/0.24 nM, and also inhibits PDGFR and c-Kit, low activity observed against FGFR-1, Flt3, c-Met EGFR and IGF-1R.

Tivozanib is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis.