Orantinib (TSU-68) supplier|cas 252916-29-3 |DC Chemicals|Supplier|Price|Buy  

Orantinib (TSU-68) supplier|cas 252916-29-3  |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Orantinib (TSU-68) supplier,cas 252916-29-3 , Cat No. DC5079, In stock

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Product name: Orantinib (TSU-68), Synonym:　TSU-68；SU6668; NSC 702827., Cat No. DC5079, Cas: 252916-29-3, Chemical Name:N/A, Molecular Formula: C28H26N4O4, MW: 482.53

Orantinib (TSU-68),cas 252916-29-3 , Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. SU6668 has greatest potency against PDGFR autophosphorylation with Ki of 8 nM, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activity against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2; does not inhibit EGFR.

Orantinib, also known as TSU-68；SU6668,  is an orally bioavailable receptor tyrosine kinase inhibitor. Orantinib binds to and inhibits the autophosphorylation of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor (PDGFR), and fibroblast growth factor receptor (FGFR), thereby inhibiting angiogenesis and cell proliferation. Orantinib also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells.