Palbociclib (PD0332991 HCl) supplier|cas 827022-32-2 |DC Chemicals|Supplier|Price|Buy  

Palbociclib (PD0332991 HCl) supplier|cas 827022-32-2 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Palbociclib (PD0332991 HCl) supplier,cas 827022-32-2, Cat No. DC5067, In stock

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Product name: Palbociclib (PD0332991 HCl), Synonym:　PD 0332991,PD-0332991, Cat No. DC5067, Cas: 827022-32-2, Chemical Name:N/A, Molecular Formula: C24H29N7O2·HCl, MW: 483.99

Palbociclib (PD0332991 HCl),cas 827022-32-2, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. Palbociclib is an oral, small molecule cyclin-dependent kinase 4/6 (CDK4/6) inhibitor, now in Phase 3 clinical development for advanced breast cancer.

Palbociclib, also known as PD0332991, is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. PD-0332991 selectively inhibits cyclin-dependent kinases (particularly Cdk4/cyclin D1 kinase), which may inhibit retinoblastoma (Rb) protein phosphorylation; inhibition of Rb phosphorylation prevents Rb-positive tumor cells from entering the S phase of the cell cycle (arrest in the G1 phase), resulting in suppression of DNA replication and decreased tumor cell proliferation. PD 0332991 is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4) (IC50 = 0.011 μmol/L) and Cdk6 (IC50 =  0.016 μmol/L), having no activity against a panel of 36 additional protein kinases.