Idelalisib (CAL-101,GS-1101) supplier|cas 870281-82-6 |DC Chemicals|Supplier|Price|Buy  

Idelalisib (CAL-101,GS-1101) supplier|cas 870281-82-6 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Idelalisib (CAL-101,GS-1101) supplier,cas 870281-82-6, Cat No. DC5068, In stock

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Product name: Idelalisib (CAL-101,GS-1101), Synonym:　Idelalisib; CAL-101,  GS-1101; GS 1101; GS1101, Cat No. DC5068, Cas: 870281-82-6, Chemical Name:N/A, Molecular Formula: C22H18FN7O, MW: 415.423

Idelalisib (CAL-101,GS-1101),cas 870281-82-6, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. CAL-101 is a selective p110δ inhibitor with IC50 of 2.5 nM; shown to have 40- to 300-fold greater selectivity for p110δ thanp110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.

Idelalisib, also known as CAL-101,  is a PI3K-delta inhibitor with potential immunomodulating and antineoplastic activities. CAL-101 inhibits the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), preventing the activation of the PI3K signaling pathway and thus inhibiting tumor cell proliferation, motility, and survival. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells. CAL-101 has [EC(50)] = 8nM.