L-755,507|CRISPR Editing Enhancer|From DC Chemicals

L-755,507|CRISPR Editing Enhancer|From DC Chemicals
L-755,507 enhances CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs).

Catlog: DC8092| Product name: L-755,507| Cas: 159182-43-1| Other names: L755,507,L-755507,L 755,507| Molecule Formula: C30H40N4O6S| MW: 584.73. Purity: >98%

Price: 100mg: 900 USD; 250mg: 1400 USD; 1000mg: 2500 USD

L-755,507 enhance CRISPR-mediated HDR efficiency, 3-fold for large fragment insertions and 9-fold for point mutations. L-755,507 was previously characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 ~0.43 nM.  It has > 1000 fold selectivity overβ1- and β2-adrenoceptors (EC50 ~ 580 nM and >10000 nM for β1- and β2-adrenoceptors respectively). It stimulates lipolysis in rhesus adipocytes in vitro (EC50 = 3.9 nM).In vitro:  L-755,507 was used at 1-5 µM final concentration in various in vitro assays.In vivo: L-755,507 stimulates metabolic rate by 30% after acute bolus intravenous administration of 0.1 mg/kg to rhesus monkeys.

For research and scientific purpose only, not for human use.