pp2 supplier|cas 172889-27-9 |DC Chemicals|Supplier|Price|Buy

pp2 supplier|cas 172889-27-9 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: pp2 supplier,cas 172889-27-9, Cat No. DC5008, In stock

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Product name: pp2, Synonym:　PP2; AG 1879, Cat No. DC5008, Cas: 172889-27-9, Chemical Name:1-(tert-butyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Molecular Formula: C15H16ClN5, MW: 301.77

pp2,cas 172889-27-9, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. PP2 is Src family kinase inhibitor, potently inhibits Lck/Fyn with IC50 of 4 nM/5 nM, ~100-fold less potent to EGFR, inactive for ZAP-70, JAK2 and PKA.

PP2 is a substance that has frequently been used in cancer research as a "selective" inhibitor for Src-family kinases. It strongly inhibits the kinases Lck (IC50=4 nM), Fyn (5 nM) and Hck (5 nM), shows weaker inhibition of EGFR (480 nM) and practically no inhibition of ZAP-70 (100 ?M) and JAK2 (50 ?M). Despite its extensive use as a Src-selective inhibitor, recent research has shown that PP2 is non-selective and inhibits many other kinases with similar affinities.