IWP-3 supplier|cas 687561-60-0 |DC Chemicals|Supplier|Price|Buy  

IWP-3 supplier|cas 687561-60-0 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: IWP-3 supplier,cas 687561-60-0, Cat No. DC5059, In stock

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Product name: IWP-3, Synonym:　N/A, Cat No. DC5059, Cas: 687561-60-0, Chemical Name:N/A, Molecular Formula: C22H17FN4O2S3, MW: 484.59

IWP-3,cas 687561-60-0, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. IWP-3 is a selective small molecule wnt inhibitor, prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity1. It blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin. It has an IC50 of 40 nM which is 100 folds less potent than Wnt-C59, but it can still efficiently promote cardiomyocyte differentiation from human ESCs.

Stemolecule Wnt Inhibitor IWP-3 was identified in a high throughput screen for antagonists of the Wnt/β-catenin pathway. Wnt Inhibitor IWP-3 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity. It also blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin. The inhibition of the Wnt pathway through the use of IWP-3 has also been shown to promote the formation of cardiocytes from human embryonic stem cell-derived mesoderm cells.