AZD1080 supplier|cas 612487-72-6 |DC Chemicals|Supplier|Price|Buy  

AZD1080 supplier|cas 612487-72-6 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: AZD1080 supplier,cas 612487-72-6, Cat No. DC5054, In stock

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Product name: AZD1080, Synonym:　AZD 1080,AZD-1080, Cat No. DC5054, Cas: 612487-72-6, Chemical Name:N/A, Molecular Formula: C19H18N4O2, MW: 334.37

AZD1080,cas 612487-72-6, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively, shows >14-fold selectivity against CDK2, CDK5, CDK1 and Erk2.

AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with a Ki of 6.9 nM and 31 nM, respectively, shows >14-fold selectivity against cdk2, cdk5, cdk1 and Erk2. AZD1080 inhibits tau phosphorylation in cells expressing human tau, with IC50 of 324 nM. AZD1080 inhibits tau phosphorylation in rat brain after oral dministration, with brain/plasma exposure ratio of 0.5 – 0.8 at peak concentrations. AZD1080 reverses cognitive deficits and rescues dysfunctional synapses in mice. Acute oral treatment with AZD1080 inhibits peripheral GSK3 activity, produces a dose-dependent reduction of the phosphorylated to total glycogen synthase (GS) ratio, with a mean maximal inhibitory effect of 49% at the highest dose (10 μmol/kg) at 2 h after dosing. [1]