Idarubicin hydrochloride|DC Chemicals

Idarubicin hydrochloride|DC Chemicals
Idarubicin Hcl is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor.

Catlog: DC8111| Product name: Idarubicin hydrochloride| Cas: 57852-57-0| Other names: | Molecule Formula: C26H28ClNO9| MW: 533.95. Purity: >98%

Price: 100mg: 400 USD; 250mg: 700 USD; 1000mg: 1300 USD

Idarubicin Hcl is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor.
IC50 Value: 3.3 ng/mL(in MCF-7 cells).
in vitro: Idarubicin is about 57.5-fold and 25-fold more active, respectively. Idarubicin is able to overcome P-glycoprotein-mediated multidrug resistance. Idarubicin inhibits PMN superoxide radical formation. Idarubicin could be coupled to the monoclonal antibodies (anti-Ly-2.1, anti-L3T4, or anti-Thy-1) with retention of protein solubility and antibody activity. Idarubicin inhibits the proliferation of NALM-6 cells with an IC50 of 12 nM.  Idarubicin inhibits CYP450 2D6. Idarubicin is much more effective than doxorubicin or epirubicin.
in vivo: Reduction of Idarubicin is dependent upon ketone reductases, and proceeds more stereoselectively than that of most ketones giving rise to the (13S)-epimer almost exclusively. The high stereospecificity in Idarubicin reduction might result from chiral induction due to the presence of asymmetric centres near to the carbonyl group in Idarubicin.

For research and scientific purpose only, not for human use.