TUG-770|cas 1402601-82-4| DC Chem|Supplier|Price|Buy 

TUG-770|cas 1402601-82-4| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: TUG-770|cas 1402601-82-4,Purity: >98% ,Cat No. DC7036, In stock.

Contact: website: www.dcchemicals.com,

sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,

Tel: +86-21-61454686;Fax:+86-21-61642505；

TUG-770|cas 1402601-82-4 ,Synonym: TUG770; TUG 770  ,Chemical name: 3-[4-[2-[2-(cyanomethyl)phenyl]ethynyl]-2-fluorophenyl]propanoicacid ,Molecular Formula:  C19H14FNO2 ,MW:307.32

TUG-770, cas 1402601-82-4,Purity: >98%, Best Price and quality from DC Chemicals. TUG-770 is a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist with EC50 of 6 nM for hFFA1.

IC50 Value: 6nM (hFFA1) [1] TUG-770 is a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes. in vitro: TUG-770 (Compound 22) displayed excellent physicochemical and in vitro ADME properties, with good aqueous solubility, good chemical stability, low lipophilicity, and decreased plasma protein binding (PPB). TUG-770 furthermore showed excellent stability toward human liver microsomes (HLM), no inhibition of selected CYP-enzymes implicated in drug-drug interactions, no P-glycoprotein (P-gp) inhibition, and good permeability in the Caco-2 cell assay [1]. in vivo: Examination of TUG-770 in an acute intraperitoneal glucose tolerance test (IPGTT) in normal mice revealed a good dose dependent response with maximal reduction in glucose level reached at 50 mg/kg. The effect of TUG-770 was fully sustained after 29 days of daily oral treatment. Additional evaluation of TUG-770 in rats confirmed a significant glucose lowering effect for the high doses already after 10 min and for all doses after 30 min [1]. Clinical trial: N/A