LY2801653 dihydrochloride|cas 1206801-37-7| DC Chem|Supplier|Price|Buy  

LY2801653 dihydrochloride|cas 1206801-37-7| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: LY2801653 dihydrochloride|cas 1206801-37-7,Purity: >98% ,Cat No. DC7035, In stock.

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LY2801653 dihydrochloride|cas 1206801-37-7 ,Synonym: LY-2801653 dihydrochloride; LY 2801653 dihydrochloride  ,Chemical name:  ,Molecular Formula: C30H24Cl2F2N6O3 ,MW:625.45

LY2801653 dihydrochloride, cas 1206801-37-7,Purity: >98%, Best Price and quality from DC Chemicals. LY2801653 2Hcl is a potent, orally bioavailable, small-molecule inhibitor of c-MET kinase(Ki= 2 nM). 

IC50 Value: 2 nM(Ki value) LY2801653 is a potent, orally bioavailable, small-molecule inhibitorLY2801653 targeting MET kinase. in vitro: LY2801653 is a type-II ATP competitive, slow-off inhibitor of MET tyrosine kinase with a dissociation constant (K(i)) of 2 nM, a pharmacodynamic residence time (K(off)) of 0.00132 min(-1) and t(1/2) of 525 min [1]. LY2801653 was found to have potent activity against several other receptor tyrosine oncokinases including MST1R, FLT3, AXL, MERTK, TEK, ROS1, DDR1/2 and against the serine/threonine kinases MKNK1/2. in vivo: LY2801653 demonstrated in vitro effects on MET pathway-dependent cell scattering and cell proliferation; in vivo anti-tumor effects in MET amplified (MKN45), MET autocrine (U-87MG, and KP4) and MET over-expressed (H441) xenograft models; and in vivo vessel normalization effects [1]. Clinical trial: LY2801653 is currently in phase 1 clinical testing in patients with advanced cancer (trial I3O-MC-JSBA, NCT01285037).