SR9009|cas 1379686-30-2|DC Chemicals

SR9009|cas 1379686-30-2|DC Chemicals

SR9009 is an agonist of  REV-ERB with IC50 = 670 nM for REV-ERBα and IC50 = 800 nM for REV-ERBβ.

Product Name: SR9009|Cat No: DC9544|Cas: 1379686-30-2|Molecule Formular: C20H24ClN3O4S|Molecule Weight: 437.9402|Other names: SR9009

SR9009 is an agonist of  REV-ERB with IC50 = 670 nM for REV-ERBα and IC50 = 800 nM for REV-ERBβ.
in vitro: SR9009 dose-dependently increases the REV-ERB-dependent repressor activity assessed in HEK293 cells expressing a chimeric Gal4 DNA Binding Domain (DBD) - REV-ERB ligand binding domain (LBD) α or β and a Gal4-responsive luciferase reporter. SR9009 potently and efficaciously suppresses transcription in a cotransfection assay using full-length REV-ERBα along with a luciferase reporter driven by the Bmal1 promoter (SR9009 IC50=710 nM). SR9009 suppresses the expression of BMAL1 mRNA in HepG2 cells in a REV-ERBα/β-dependent manner.
in vivo: SR9009 are synthetic REV-ERB agonists with activity. SR9009 also inhibits the activity of the SCN clock, with reversible inhibition of circadian oscillations in SCN explants cultured from the Per2:luc reporter mouse.

For research only, not for human use!