Cilomilast|cas 153259-65-5|DC Chemicals

Cilomilast|cas 153259-65-5|DC Chemicals

Cilomilast(SB 207499; Ariflo) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity.

IC50 value: 110 nM

Target: PDE 4

Cilomilast (SB-207499) inhibits HPDE4 and LPDE4 catalytic activity with equal potency (Ki ≈100 nM).

Product Name: Cilomilast|Cat No: DC9582|Cas: 153259-65-5|Molecule Formular: C20H25NO4|Molecule Weight: 343.4168|Other names: Cilomilast

Cilomilast(SB 207499; Ariflo) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity.
Cilomilast (SB-207499) inhibits HPDE4 and LPDE4 catalytic activity with equal potency (Ki ≈100 nM). SB-207499 and rolipram are equipotent against LPDE4, but Cilomilast (Ariflo, SB-207499) is 100-fold less potent against HPDE4. This profile suggests that Cilomilast (Ariflo, SB-207499) retain the anti-inflammatory activity of rolipram yet have a decreased tendency to produce side effects.

For research only, not for human use!