FIIN-3，FIIN3|CAS 1637735-84-2

FIIN-3，FIIN3|CAS 1637735-84-2

FIIN-3 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor.

Product Name: FIIN-3|Cat No: DC9642|Cas: 1637735-84-2 |Molecule Formular: C34H36Cl2N8O4 |Molecule Weight: 690.22|Other names: FIIN-3

FIIN-3 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor. FIIN-3 is the first inhibitor that can potently inhibit the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, which confer resistance to first-generation clinical FGFR inhibitors such as NVP-BGJ398 and AZD4547. FIIN-3 has the unprecedented ability to inhibit both the EGF receptor (EGFR) and FGFR covalently by targeting two distinct cysteine residues. FIIN-3 bound with FGFR4 V550L and EGFR L858R.

For research only, not for human use!