Nafamostat (mesylate)|cas 82956-11-4|DC Chemicals

Nafamostat (mesylate)|cas 82956-11-4|DC Chemicals

Nafamostat mesylate, a synthetic serine protease inhibitor, is an anticoagulant.

Target: Serine Protease

Tranilast (FUT-175) is an antiallergic drug for bronchial asthma.

Product Name: Nafamostat (mesylate)|Cat No: DC9619|Cas: 82956-11-4|Molecule Formular: C21H25N5O8S2|Molecule Weight: 539.5819|Other names: Nafamostat (mesylate)

Nafamostat mesylate, a synthetic serine protease inhibitor, is an anticoagulant.
Tranilast (FUT-175) is an antiallergic drug for bronchial asthma. It has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. It has also been investigated for use as an antiproliferative drug on drug-eluting stents.
A 20-40 mg/h dose of FUT-175 prolonged coagulation time sufficiently in the instrumental blood of the extracorporeal circuit but not in the systemic blood. Its anticoagulant activity decreased immediately after hemodialysis. Therefore, we could manage all patients without any bleeding trouble during hemodialysis with FUT-175 as an anticoagulant. Although there were side effects of FUT-175, such as nausea, vomiting, itching and eruption, they were not serious, and FUT-175 could be administered without interruption. FUT-175 seems to be useful as an anticoagulant during hemodialysis for patients susceptible to bleeding.

For research only, not for human use!