(S)-(+)-Rolipram|cas 85416-73-5|DC Chemicals

(S)-(+)-Rolipram|cas 85416-73-5|DC Chemicals

(S)-(+)-Rolipram is a PDE4-inhibitor and an anti-inflammatory agent, less potent than its R enantiomer.

Target: PDE4B; PDE4D

Rolipram, a selective inhibitor of the cyclic AMP-specific phosphodiesterase (PDE IV)..

Product Name: (S)-(+)-Rolipram|Cat No: DC9581|Cas: 85416-73-5|Molecule Formular: C16H21NO3|Molecule Weight: 275.3428|Other names: (S)-(+)-Rolipram

(S)-(+)-Rolipram is a PDE4-inhibitor and an anti-inflammatory agent, less potent than its R enantiomer.
Rolipram, a selective inhibitor of the cyclic AMP-specific phosphodiesterase (PDE IV). Rolipram did not inhibit 5-lipoxygenase activity but did inhibit human monocyte production of leukotriene B4 (LTB4, IC50 3.5 microM). Rolipram inhibited arachidonic acid-induced inflammation in the mouse, while the low Km-cyclic-GMP PDE inhibitor. Rolipram had a modest effect on LTB4 production in the mouse, but markedly reduced LTB4-induced PMN infiltration. In humans and animals rolipram produces thereby a variety of biological effects. These effects include attenuation of endogenous depression and inflammation in the central nervous system (CNS), both effects are of potential clinical relevance.

For research only, not for human use!