A 419259 (trihydrochloride)|cas 1435934-25-0|DC Chemicals

A 419259 (trihydrochloride)|cas 1435934-25-0|DC Chemicals

A 419259 3Hcl is an apoptosis inducing agent that inhibits Src family kinases (c-Src).

Product Name: A 419259 (trihydrochloride)|Cat No: DC9628|Cas: 1435934-25-0|Molecule Formular: C29H37Cl3N6O|Molecule Weight: 592.0027|Other names: A 419259 (trihydrochloride)

A 419259 3Hcl is an apoptosis inducing agent that inhibits Src family kinases (c-Src). A 419259 also induces apoptosis in CML cell ines and blocks Stat5 and Erk activation.
in vitro: Treatment of the Ph+ CML cell lines K-562 and Meg-01 with A-419259 resulted in growth arrest and induction of apoptosis, while the Ph- leukemia cell lines TF-1 and HEL were unaffected over the same concentration ranges. Suppression of Ph+ cell growth by A-419259 correlated with a decrease in Src kinase autophosphorylation. A-419259 blocked Stat5 and Erk activation, consistent with the suppressive effects of the compounds on survival and proliferation. A-419259 treatment blocks all Src-family kinase activity in ES cells, preventing differentiation while maintaining pluripotency. Expression of inhibitor-resistant c-Src but not c-Yes rescued the A-419259 differentiation block, resulting in a cell population with properties of both primitive ectoderm and endoderm.  Blockade of Src family kinases using an Src-specific tyrosine kinase inhibitor A-419259 decreased GRP-induced EGFR phosphorylation and MAPK activation in HNSCC.

For research only, not for human use!