Poloxin|cas 321688-88-4|DC Chemicals

Poloxin|cas 321688-88-4|DC Chemicals

Poloxin is a non-ATP competitive Polo-like Kinase 1 (PLK1) inhibitor that targets the polo-box domain.

Product Name: Poloxin|Cat No: DC9594|Cas: 321688-88-4|Molecule Formular: C18H19NO3|Molecule Weight: 297.3484|Other names: Poloxin

Poloxin is a non-ATP competitive Polo-like Kinase 1 (PLK1) inhibitor that targets the polo-box domain.
in vitro: Poloxin induces centrosome fragmentation and abnormal spindle and chromosome misalignment, which activate the spindle assembly checkpoint and prolong mitosis. Notably, centrosomal fragmentation induced by Poloxin is partially attributable to dysfunctional Kizuna, a key substrate of Plk1 at centrosomes. Moreover, Poloxin strongly inhibits proliferation of a panel of cancer cells by inducing mitotic arrest, followed by a surge of apoptosis.
in vivo: Poloxin inhibit tumor growth in nude mice xenografted with MDA-MB-231 or HeLa cells. A significant reduction of tumor volume after approximately 6 weeks of treatment with Poloxin or TQ in MDA-MB-231 xenograft mice compared with vehicle DMSO treatment.

For research only, not for human use!