Bay 60-7550|cas 439083-90-6|DC Chemicals

Bay 60-7550|cas 439083-90-6|DC Chemicals

Bay 60-7550 is a potent PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human); 50-fold more selective for PDE2 compared to PDE1 and greater than 100-fold selective compared to PDE5, PDE3B, PDE4B, PDE7B, PDE8A, PDE9A, PDE10A, and PDE11A.

IC50 value: 2.0 nM/4.7 nM (bovine/human PDE2)

Target: PDE2

At 3 mg/kg BAY-60-7550 antagonizes oxidative stress-induced anxiety-like behavioral effects in mice by increasing cGMP signaling.At 1 mg/kg BAY-60-7550 improves the performance of rats in an object location task, enhancing cAMP/cGMP-mediated object and spatial memory consolidation.

Product Name: Bay 60-7550|Cat No: DC9578|Cas: 439083-90-6|Molecule Formular: C27H32N4O4|Molecule Weight: 476.5674|Other names: Bay 60-7550

Bay 60-7550 is a potent PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human); 50-fold more selective for PDE2 compared to PDE1 and greater than 100-fold selective compared to PDE5, PDE3B, PDE4B, PDE7B, PDE8A, PDE9A, PDE10A, and PDE11A.
At 3 mg/kg BAY-60-7550 antagonizes oxidative stress-induced anxiety-like behavioral effects in mice by increasing cGMP signaling.At 1 mg/kg BAY-60-7550 improves the performance of rats in an object location task, enhancing cAMP/cGMP-mediated object and spatial memory consolidation. Bay 60-7550 is useful for improving memory.

For research only, not for human use!