JNJ-42165279|JNJ42165279|FAAH inhibitor

JNJ-42165279|JNJ42165279|FAAH inhibitor

JNJ-42165279 is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC50 of 70nM.

Product Name: JNJ-42165279|Cat No: DC9662|Cas: 1346528-50-4|Molecule Formular: C18H17ClF2N4O3|Molecule Weight: 410.8|Other names: JNJ-42165279

 JNJ-42165279 exhibited excellent ADME and pharmacodynamic properties as evidenced by its ability to block FAAH in the brain and periphery of rats and thereby cause an elevation of the concentrations of anandamide (AEA), oleoyl ethanolamide (OEA), and palmitoyl ethanolamide (PEA). The compound was also efficacious in the spinal nerve ligation (SNL) model of neuropathic pain. The combination of good physical, ADME, and PD properties of JNJ-42165279 supported it entering the clinical portfolio.

For research only, not for human use.