Lck Inhibitor|cas 847950-09-8|DC Chemicals

Lck Inhibitor|cas 847950-09-8|DC Chemicals

Lck Inhibitor is a new class of compounds that are potent inhibitors of Lck with an IC50 value of 7 nM.

IC50 Value: 7 nM [1]

Target: Lck

in vitro: Lck Inhibitor (compound 25) exhibited good potency in the T-cell receptor-induced IL-2 secretion assay (IL- 2) and also inhibited subsequent T-cell proliferation (T-cell prolif.) in the same human T -cells.

in vivo: A once daily dose of 25was administered orally at 10, 30, and 60 mg/kg from day 9 today 17.

Product Name: Lck Inhibitor|Cat No: DC9626|Cas: 847950-09-8|Molecule Formular: C31H30N8O|Molecule Weight: 530.6229|Other names: Lck Inhibitor

Lck Inhibitor is a new class of compounds that are potent inhibitors of Lck with an IC50 value of 7 nM.
in vitro: Lck Inhibitor (compound 25) exhibited good potency in the T-cell receptor-induced IL-2 secretion assay (IL- 2) and also inhibited subsequent T-cell proliferation (T-cell prolif.) in the same human T -cells.
in vivo: A once daily dose of 25was administered orally at 10, 30, and 60 mg/kg from day 9 today 17. Paw volume was measured daily from day 9 through day 18. The compound showed a dose-dependent inhibition of arthritis, with an ED50 estimated at 24 mg/kg (Figure 6). Based on the measured plasma levels from the three dose groups, the exposure of 25 at the ED50 was estimated to be 2.7 μM·h (Cmax≈ 0.7 μM).

For research only, not for human use!