Formoterol (Fumarate)|cas 43229-80-7|DC Chemicals

Formoterol (Fumarate)|cas 43229-80-7|DC Chemicals

Formoterol fumarate(Foradil) is a potent, selective and long-acting β2-adrenoceptor agonist.

IC50 Value: 2.1 nM in pregnant C3H/HeN strain mice[5]

Target: β2 receptor

Budesonide/formoterol in a single inhaler for both maintenance and reliever therapy is now an established therapeutic option for management of inadequately controlled asthma[4].

in vitro:.

Product Name: Formoterol (Fumarate)|Cat No: DC9333|Cas: 43229-80-7|Molecule Formular: C42H52N4O12|Molecule Weight: 804.8819|Other names: Formoterol (Fumarate)

Formoterol fumarate(Foradil) is a potent, selective and long-acting β2-adrenoceptor agonist.
Budesonide/formoterol in a single inhaler for both maintenance and reliever therapy is now an established therapeutic option for management of inadequately controlled asthma.
in vitro:. The long-acting β(2)-agonist formoterol and the glucocorticoid dexamethasone significantly reduced HRV-induced ERK phosphorylation, Fra-1, and MMP-9 expression in BEAS-2B cells.
in vivo: compared the bronchodilatory effects of inhaled budesonide/formoterol (dose: 200 μg and 12 μg respectively) combination with budesonide (200 μg)/salbutamol (200 μg) administered by metered dose inhaler and spacer in children of 5-15 years with mild acute exacerbation of asthma [Modified Pulmonary Index Score (MPIS) between 6-8] in this double-blind, randomized controlled trial. The primary outcome was FEV1 (% predicted) in the two groups at 1, 5, 15, 30, 60 min after administration of the study drug. Fifteen randomized, placebo-controlled clinical trials including COPD patients were evaluated: indacaterol 75 μg once daily (n = 2 studies), indacaterol 150 μg once daily (n = 5), indacaterol 300 μg once daily (n = 4), FOR/BUD 9/160 μg twice daily (n = 2), FOR/BUD 9/320 μg twice daily (n = 2), SAL/FP 50/500 μg twice daily (n = 4), and SAL/FP 50/250 μg twice daily (n = 1).

For research only, not for human use!