AIM-100|cas 873305-35-2|DC Chemicals

AIM-100|cas 873305-35-2|DC Chemicals

AIM-100 is a small molecule inhibitor of Ack1 with an IC50 of 24 nM

IC50 value: 24 nM [3]

Target: Ack1

Ack1 inhibitor AIM-100 not only inhibited Ack1 activation but also suppressed AKT tyrosine phosphorylation, leading to cell cycle arrest in the G1 phase [1].The Ack1 inhibitor AIM-100 not only inhibited Ack1 activity but also was able to suppress AR Tyr(267) phosphorylation and its recruitment to the ATM enhancer.

Product Name: AIM-100|Cat No: DC9330|Cas: 873305-35-2|Molecule Formular: C23H21N3O2|Molecule Weight: 371.4317|Other names: AIM-100

AIM-100 is a small molecule inhibitor of Ack1 with an IC50 of 24 nM
Ack1 inhibitor AIM-100 not only inhibited Ack1 activation but also suppressed AKT tyrosine phosphorylation, leading to cell cycle arrest in the G1 phase.The Ack1 inhibitor AIM-100 not only inhibited Ack1 activity but also was able to suppress AR Tyr(267) phosphorylation and its recruitment to the ATM enhancer. Notably, AIM-100 suppressed Ack1 mediated ATM expression and mitigated the growth of radioresistant CRPC tumors. AIM-100, not only inhibited Ack1 activation but also able to suppress pTyr267-AR phosphorylation, binding of AR to PSA, NKX3.1, and TMPRSS2 promoters, and inhibit AR transcription activity.

For research only, not for human use!