TGX221|cas 663619-89-4| DC Chem|Supplier|Price|Buy  

TGX221|cas 663619-89-4| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: TGX221|cas 663619-89-4,Purity: >98% ,Cat No. DC7321, In stock.

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TGX221|cas 663619-89-4 ,Synonym: TGX221; TGX 221  ,Chemical name: 7-methyl-2-morpholino-9-(1-(phenylamino)ethyl)-4H-pyrido[1,2-a]pyrimidin-4-one ,Molecular Formula: C21H24N4O2 ,MW:364.44

TGX221, cas 663619-89-4,Purity: >98%, Best Price and quality from DC Chemicals. TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110β .

The activity of TGX-221 against different isoforms is measured in an in vitro PI3K assay using multiple preparations of recombinant p85/p110. TGX-221 show slow potent to p110δ with IC50 of 211 nM. Furthermore, TGX-221 partially attenuates insulin-induced phosphorylation of Ser473 of PKB in J774.2 macrophage cells. [1]TGX-221 inhibits platelet-ECC interaction, platelet aggregation and platelet-granulocyte binding in an extracorporeal circulation (ECC) model. [2] A recent study shows that after treatment with TGX-221 (0.2, 2, and 20 μM), PC3 cells show inhibition of proliferation with a significant reduction of the activity of the p110β PI3K isoform. [3] As an anti-thrombotic agent, TGX-221 at doses 1 + 1 (49 %) and 3+3 (88 %) improves integrated blood flow over 30 minutes in a mouse model. In addition, Tail bleeding time (BT) (sec) increases with TGX-221 doses of 3 + 3 (median 1560) and 1 + 1 (1305) and mean renal BT (sec) also increases in all TGX-221 groups. [4]