R1487|cas 449808-64-4| DC Chem|Supplier|Price|Buy  

R1487|cas 449808-64-4| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: R1487|cas 449808-64-4,Purity: >98% ,Cat No. DC7322, In stock.

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R1487|cas 449808-64-4 ,Synonym:  ,Chemical name: 6-(2,4-difluorophenoxy)-8-methyl-2-(oxan-4-ylamino)pyrido[2,3-d]pyrimidin-7-one ,Molecular Formula: C19H19CIF2N4O3 ,MW:424.83

R1487, cas 449808-64-4,Purity: >98%, Best Price and quality from DC Chemicals. R1487 is a p38 MAP kinase inhibitor with an IC50 of 10nM. It may have potential as a treatment for inflammatory diseases such as rheumatoid arthritis.

The development of a new series of p38α inhibitors resulted in the identification of two clinical candidates, one of which was advanced into a phase 2 clinical study for rheumatoid arthritis. The original lead, an lck inhibitor that also potently inhibited p38α, was a screening hit from our kinase inhibitor library. This manuscript describes the optimization of the lead to p38-selective examples with good pharmacokinetic properties.[1]