Talnetant (SB 223412) |cas 174636-32-9| DC Chem|Supplier|Price|Buy  

Talnetant (SB 223412) |cas 174636-32-9| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: Talnetant (SB 223412) |cas 174636-32-9,Purity: >98% ,Cat No. DC7244, In stock.

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Talnetant (SB 223412) |cas 174636-32-9 ,Synonym: SB-223412; SB223412; SB 223412  ,Chemical name: 3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide ,Molecular Formula:  C25H22N2O2 ,MW:382.45438 

Talnetant (SB 223412) , cas 174636-32-9,Purity: >98%, Best Price and quality from DC Chemicals. Talnetant (SB 223412) is a potent and selective NK3 receptor antagonist(ki=1.4 nM, hNK-3-CHO); 100-fold selective for the hNK-3 versus hNK-2 receptor, with no affinity for the hNK-1 at concentrations up to 100 uM.

Potent and selective non-peptide NK3 receptor antagonist (Ki values are 1, 144 and >100000 nM for human NK3, NK2 and NK1 receptors respectively). Selective over a panel of >60 receptors, enzymes and ion channels at concentrations of 1 or 10 μM. Inhibits NKB-induced Ca2+ mobilization in vitro (IC50= 16.6 nM) and inhibits NK3-agonist-induced behavioral responses in vivo. Orally active and brain penetrant.