TAK-733|cas 1035555-63-5| DC Chem|Supplier|Price|Buy 

TAK-733|cas 1035555-63-5| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: TAK-733|cas 1035555-63-5,Purity: >98% ,Cat No. DC7308, In stock.

Contact: website: www.dcchemicals.com,

sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,

Tel: +86-21-61454686;Fax:+86-21-61642777；

TAK-733|cas 1035555-63-5 ,Synonym: TAK733; TAK 733  ,Chemical name: (R)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione ,Molecular Formula: C17H15F2IN4O4 ,MW:504.23

TAK-733, cas 1035555-63-5,Purity: >98%, Best Price and quality from DC Chemicals. TAK-733 is a potent and selective MEK allosteric site inhibitor for MEK1 with IC50 of 3.2 nM, inactive to Abl1, AKT3, c-RAF, CamK1, CDK2, c-Met, etc.

TAK-733 is highly potent and selective MEK allosteric site inhibitor with IC50 of 3.2 nM. TAK-733 shows potent enzymatic and cell activity with an EC50 of 1.9 nM against ERK phosphorylation in cells. TAK-733 demonstrates broad antitumor activity in mouse xenograft models of human cancer including models of melanoma, colorectal, NSCLC, pancreatic and breast cancer. TAK-733 is well tolerated with pharmacokinetics and pharmacodynamics that support once-daily oral dosing in humans. [1] TAK-733 shows maximally efficacious doses at once daily orally doses of 10 mg/kg.