SCH-772984|cas 942183-80-4| DC Chem|Supplier|Price|Buy  

SCH-772984|cas 942183-80-4| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: SCH-772984|cas 942183-80-4,Purity: >98% ,Cat No. DC7283, In stock.

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SCH-772984|cas 942183-80-4 ,Synonym: SCH 772984; SCH-772984  ,Chemical name: (R)-1-(2-oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide ,Molecular Formula: C33H33N9O2 ,MW:587.67

SCH-772984, cas 942183-80-4,Purity: >98%, Best Price and quality from DC Chemicals. SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.

SCH772984 is a novel, selective and ATP competitive inhibitor of ERK1/2. SCH772984 inhibits phosphorylation of the ERK substrate p90 ribosomal S6 kinase (T359/S363 phospho-RSK) in a dose-dependent manner. SCH772984 also inhibits phosphorylation of residues in the activation loop of ERK itself. SCH772984 demonstrates EC50 values <500 nM in approximately 88% and 49% of BRAF-mutant or RAS-mutant tumor lines, respectively. Importantly, SCH772984 effectively inhibited MAPK signaling and cell proliferation in tumor cells resistant to concurrent treatment with BRAF and MEK inhibitors. [1] SCH772984 induces tumor regressions in xenograft models at tolerated doses. SCH772984 effectively inhibites MAPK signaling and cell proliferation in BRAF or MEK inhibitor resistant models. [1]