Purvalanol B(NG-95)|cas 212844-54-7| DC Chem|Supplier|Price|Buy  

Purvalanol B(NG-95)|cas 212844-54-7| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: Purvalanol B(NG-95)|cas 212844-54-7,Purity: >98% ,Cat No. DC7256, In stock.

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Purvalanol B(NG-95)|cas 212844-54-7 ,Synonym: NG 95; NG95; NG-95  ,Chemical name: 2-chloro-4-[[2-[[(2R)-1-hydroxy-3-methylbutan-2-yl]amino]-9-propan-2-ylpurin-6-yl]amino]benzoicacid ,Molecular Formula: C20H25ClN6O3 ,MW:432.9

Purvalanol B(NG-95), cas 212844-54-7,Purity: >98%, Best Price and quality from DC Chemicals. Purvalanol B(NG-95) is a cyclin-dependent kinase inhibitor with IC50 values of 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. 

Purvalanol B has been shown to be a cyclin-dependent kinase inhibitor. IC50 values are 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. This compound has also been shown to have antiproliferative properties, mediated by p42/p44 MAPK. IC50 Value: 6 nM (CDK1/cyclinB); 9 nM (cdk2/cyclin E); 6 nM (cdk5/p35 ) [1] Target：CDKs in vitro: In vitro inhibitory activity against Cyclin-dependent kinase 1-cyclin B complex from starfish oocytes is 6 nM (IC50) [1]. In addition to CDK1, p42/p44 MAPK were found to be two major purvalanol-interacting proteins in five different mammalian cell lines (CCL39, PC12, HBL100, MCF-7 and Jurkat cells), suggesting the generality of the purvalanol/p42/p44 MAPK interaction. When cells were treated with purvalanol, p42/p44 MAPK and CDK1 activities were inhibited in a dose-dependent manner. Furthermore, purvalanol inhibited the nuclear accumulation of p42/p44 MAPK, an event dependent on the catalytic activity of these kinases [2].