Purmorphamine|cas 483367-10-8| DC Chem|Supplier|Price|Buy  

Purmorphamine|cas 483367-10-8| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: Purmorphamine|cas 483367-10-8,Purity: >98% ,Cat No. DC7255, In stock.

Contact: website: www.dcchemicals.com,

sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,

Tel: +86-21-61454686;Fax:+86-21-61642724；

Purmorphamine|cas 483367-10-8 ,Synonym:  ,Chemical name: 9H-Purin-6-amine,9-cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)- ,Molecular Formula: C31H32N6O2 ,MW:520.62

Purmorphamine, cas 483367-10-8,Purity: >98%, Best Price and quality from DC Chemicals. Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM and also is an inducer of osteoblast differentiation with EC50 of 1 μM.

Purmorphamine activates the Hedgehog pathway by directly binds and activates Smoothened with IC50 of ~ 1.5 μM in compete with cyclopamine, a Smo antagonist. [1] Purmorphamine is a potent inducer of osteogenesis in multipotent C3H10T1/2 cells. The EC50 (based on ALP expression) for Purmorphamine is 1 μM in C3H10T1/2 cells. Purmorphamine (1 μM) and BMP-4 (100 ng/mL) together increase ALP activity more than 90-fold in 3T3-L1 cells. [2] In contrast to BMP-4, Purmorphamine induces osteogenesis by activating Hedgehog signaling in multipotent mesenchymal progenitor cells. [3] Purmorphamine up-regulates ALP expression in human mesenchymal stem cell-based constructs on rats. [4]