PND-1186|cas 1356154-94-3| DC Chem|Supplier|Price|Buy  

PND-1186|cas 1356154-94-3| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: PND-1186|cas 1356154-94-3,Purity: >98% ,Cat No. DC7241, In stock.

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PND-1186|cas 1356154-94-3 ,Synonym: SR-2516; PND 1186; PND1186; SR 2516; SR2516  ,Chemical name: 2-((2-((2-methoxy-4-morpholinophenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamidehydrochloride. ,Molecular Formula:  C25H27ClF3N5O3 ,MW:537.96

PND-1186, cas 1356154-94-3,Purity: >98%, Best Price and quality from DC Chemicals. PND-1186 is a potent FAK inhibitor with IC50 of 1.5 nM.

PND-1186, also known as SR-2156,  is a potent FAK inhibitor with a 50% inhibitory concentration (IC50) of 1.5 nM in vitro. PND-1186 has an IC50 of ~100 nM in breast carcinoma cells. Notably, 1.0 ?M PND-1186 (>5-fold above IC50) had limited effects on cell proliferation. However, under non-adherent conditions as spheroids and as colonies in soft agar, 0.1 ?M PND-1186 blocked FAK and p130Cas tyrosine phosphorylation, promoted caspase-3 activation, and triggered cell apoptosis. PND-1186 inhibited 4T1 breast carcinoma subcutaneous tumor growth correlated with elevated tumor cell apoptosis and caspase 3 activation. Addition of PND-1186 to the drinking water of mice was well tolerated and inhibited ascites- and peritoneal membrane-associated ovarian carcinoma tumor growth associated with the inhibition of FAK Tyr-397 phosphorylation.