Dolutegravir (GSK1349572)|cas 1051375-16-6| DC Chem|Supplier|Price|Buy  

Dolutegravir (GSK1349572)|cas 1051375-16-6| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: Dolutegravir (GSK1349572)|cas 1051375-16-6,Purity: >98% ,Cat No. DC7273, In stock.

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Dolutegravir (GSK1349572)|cas 1051375-16-6 ,Synonym: S/GSK1349572; GSK1349572; S/GSK 1349572; GSK-1349572; GSK 1349572  ,Chemical name: 2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide,N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-,(4R,12aS)- ,Molecular Formula: C20H19F2N3O5 ,MW:419.38

Dolutegravir (GSK1349572), cas 1051375-16-6,Purity: >98%, Best Price and quality from DC Chemicals. Dolutegravir (DTG, GSK1349572) is an integrase inhibitor(IC50= 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.

S/GSK1349572 shows the potent inhibitory effect on nine clinical isolates from integrase inhibitor-na?ve HIV-2-infected patients with EC50 ranging from 0.2 nM -1.4 nM. [1] In vitro, S/GSK1349572 inhibits recombinant HIV-1 integrase-catalyzed strand transfer with IC50 of 2.7 nM. Furthermore, S/GSK1349572 potently inhibits HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector with EC50 of 0,51 nM, 0.71 nM and 2.2 nM, respectively. [2] In vitro, S/GSK1349572 exhibits potent activity against five different nonnucleoside reverse transcription inhibitor--resistant or nucleoside reverse transcription inhibitor--resistant viruses with EC50 ranging from 1.3 nM -2.1 nM. Similarly to that against wild-type virus, S/GSK1349572 shows equivalent activity against two protease inhibitor-resistant viruses with EC50 of 0.36 nM and 0.37 nM, respectively.