A83-01|cas 909910-43-6| DC Chem|Supplier|Price|Buy  

A83-01|cas 909910-43-6| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: A83-01|cas 909910-43-6,Purity: >98% ,Cat No. DC7286, In stock.

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A83-01|cas 909910-43-6 ,Synonym: A83-01; A-83-01 ,Chemical name: 3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide ,Molecular Formula: C25H19N5S ,MW:421.51686 

A83-01, cas 909910-43-6,Purity: >98%, Best Price and quality from DC Chemicals. A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively).

Selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively). Blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Only weakly inhibits ALK-1, -2, -3, -6 and MAPK activity. More potent than SB 431542 (Cat.No. 1614). Inhibits differentiation of rat induced pluripotent stem cells (riPSCs) and increases clonal expansion efficiency. Helps maintain homogeneity and long-term in vitro self-renewal of human iPSCs.