ZCL 278|cas 587841-73-4| DC Chem|Supplier|Price|Buy  

ZCL 278|cas 587841-73-4| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: ZCL 278|cas 587841-73-4,Purity: >98% ,Cat No. DC7344, In stock.

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ZCL 278|cas 587841-73-4 ,Synonym: ZCL 278; ZCL-278  ,Chemical name: 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-?[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]pheny?l]amino]thioxomethyl]acetamide ,Molecular Formula: C21H19BrClN5O4S2 ,MW:584.89

ZCL 278, cas 587841-73-4,Purity: >98%, Best Price and quality from DC Chemicals. ZCL278 is a Cdc42 small molecule modulator that directly binds to Cdc42 (Kd=11.4 uM) and inhibits Cdc42-intersectin interaction. 

ZCL278 inhibits Cdc42 GTPase activity by the competition with GTP and inhibits Rac/Cdc42 phosphorylation in a time-dependent manner. ZCL278 (50 μM) inhibits Cdc42-mediated microspike formation and disrupts GM130-docked Golgi structures in serum-starved Swiss 3T3 fibroblasts. In addition, ZCL278 also suppresses Cdc42-mediated neuronal branching and growth cone dynamics as well as actin-based motility and migration in a metastatic prostate cancer PC-3 cell line without cytotoxicity. [1]