UPF 1069|cas 1048371-03-4| DC Chem|Supplier|Price|Buy  

UPF 1069|cas 1048371-03-4| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: UPF 1069|cas 1048371-03-4,Purity: >98% ,Cat No. DC7334, In stock.

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UPF 1069|cas 1048371-03-4 ,Synonym: UPF-1069; UPF1069  ,Chemical name: 1(2H)-Isoquinolinone,5-(2-oxo-2-phenylethoxy)- ,Molecular Formula: C17H13NO3 ,MW:279.29

UPF 1069, cas 1048371-03-4,Purity: >98%, Best Price and quality from DC Chemicals. UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM; ~27-fold selective against PARP1.

UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM while inhibiting PARP1 with IC50 of 8 μM .In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 mM) causes a concentration-dependent exacerbation (up to 155%) of oxygen-glucose deprivation (OGD)-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, have no effect on OGD injury. In mouse mixed cortical cells exposed to OGD, UPF-1069 (1-10 mM) significantly reduces post-ischaemic damage.