Tenovin-3|cas 1011301-27-1| DC Chem|Supplier|Price|Buy  

Tenovin-3|cas 1011301-27-1| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: Tenovin-3|cas 1011301-27-1,Purity: >98% ,Cat No. DC7314, In stock.

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Tenovin-3|cas 1011301-27-1 ,Synonym:  ,Chemical name: 1-(4-AMino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea ,Molecular Formula: C18H21N3OS ,MW:327.44384

Tenovin-3, cas 1011301-27-1,Purity: >98%, Best Price and quality from DC Chemicals. Tenovin-3 is a small molecule activator of p53 transcriptional activity.

Tenovin-3 is a small molecule activator of p53 transcriptional activity. At 10 ?M, it elevates p53 expression in MCF-7 cells within two hours of treatment and longer-term exposure significantly decreases the growth of BL2 Burkitt’s lymphoma and ARN8 melanoma cells.1 Functioning upstream of p53, tenovin-3 acts by inhibiting the deacetylase activity of purified human SIRT1 and SIRT2, members of NAD+-dependent class III histone deacetylases that belong to the sirtuin family.1 While tenovin-3 demonstrates low genotoxicity, the compound has poor water solubility, which limits its uses in vivo.