SSR128129E|cas 848318-25-2| DC Chem|Supplier|Price|Buy  

SSR128129E|cas 848318-25-2| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: SSR128129E|cas 848318-25-2,Purity: >98% ,Cat No. DC7301, In stock.

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SSR128129E|cas 848318-25-2 ,Synonym: SSR128129E; SSR 128129E; SSR-128129E. ,Chemical name: Benzoicacid,2-amino-5-[(1-methoxy-2-methyl-3-indolizinyl)carbonyl]-,sodiumsalt(1:1) ,Molecular Formula: C18H15N2O4.Na ,MW:346.31

SSR128129E, cas 848318-25-2,Purity: >98%, Best Price and quality from DC Chemicals. SSR128129E is an orally-active and allosteric FGFR1 inhibitor with IC50 of 1.9 μM, while not affecting other related RTKs.

 SSR128129E (SSR) is an potent FGFR inhibitor, which inhibits fibroblast growth factor receptor (FGFR) signaling by binding to the extracellular FGFR domain without affecting orthosteric FGF binding. SSR128129E exhibits allosteric properties, including probe dependence, signaling bias, and ceiling effects. Inhibition by SSR128129E is highly conserved throughout the animal kingdom. Oral delivery of SSR128129E inhibits arthritis and tumors that are relatively refractory to anti-vascular endothelial growth factor receptor-2 antibodies. Thus, orally-active extracellularly acting small-molecule modulators of RTKs with allosteric properties can be developed and may offer opportunities to improve anticancer treatment.