SRPIN340|cas 218156-96-8| DC Chem|Supplier|Price|Buy  

SRPIN340|cas 218156-96-8| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: SRPIN340|cas 218156-96-8,Purity: >98% ,Cat No. DC7299, In stock.

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SRPIN340|cas 218156-96-8 ,Synonym: SRPIN 340; SRPIN-340; SRPK inhibitor  ,Chemical name: 4-Pyridinecarboxamide,N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]- ,Molecular Formula: C18H18F3N3O ,MW:349.35

SRPIN340, cas 218156-96-8,Purity: >98%, Best Price and quality from DC Chemicals. SRPIN340 is a selective SRPK inhibitor with Ki of 0.89 μM for SRPK1, showing no significant inhibitory activity against more than 140 other kinases..

SRPIN340 inhibits SR phosphorylation by SRPK in Flp-In293 cells and promotes degradation of SRp75 in a dose-dependent manner, which subsequently inhibits HIV production. SRPIN340 dose (5 mg/mL) produces no abnormalities in chromosomal structure and chromosome number of CHO cells. SRPIN340 suppresses in a dose-dependent fashion expression of a HCV subgenomic replicon and replication of the HCV-JFH1 clone in vitro. SRPIN340 inhibits CNV formation in a dose-dependent manner in vivo. SRPIN340 significantly decreases the protein levels of VEGF, MCP-1, ICAM-1, and consequently inhibits macrophage infiltration.